The Complete Source of Information

Context:Wepreviously detected a dynamic wave of gray matter loss in childhood-onset schizophrenia that started in parietal association cortices and proceeded frontally to envelop dorsolateral prefrontal and temporal cortices, including superior temporal gyri.

Objective: To map gray matter loss rates across the medial hemispheric surface, including the cingulate and medial frontal cortex, in the same cohort studied previously.
Design: Five-year longitudinal study.


Setting: National Institute of Mental Health, Bethesda, Md.

Subjects: Twelve subjects with childhood-onset schizophrenia, 12 healthy controls, and 9 medication- and IQmatched subjects with psychosis not otherwise specified.

Interventions: Three-dimensional magnetic resonance imaging at baseline and follow-up.

Main Outcome Measures: Gyral pattern and shape variations encoded by means of high-dimensional elastic deformation mappings driving each subject’s cortical anatomy onto a group average; changes in cortical gray matter mapped by computing warping fields that matched sulcal patterns across hemispheres, subjects, and time.

Results: Selective, severe frontal gray matter loss occurred bilaterally in a dorsal-to-ventral pattern across the medial hemispheric surfaces in the schizophrenic subjects.
A sharp boundary in the pattern of gray matter loss separated frontal regions and cingulate-limbic areas.

Conclusion: Frontal and limbic regions may not be equally vulnerable to gray matter attrition, which is consistent with the cognitive, metabolic, and functional vulnerability of the frontal cortices in schizophrenia. Read the rest of this entry »

Related posts

• Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine (0)
• Negative symptoms: A review of schizophrenia, melancholic depression and Parkinson’s disease (0)
• Dynamic mapping of human cortical development during childhood through early adulthood (0)
• Neuropsychology : ANXIETY (0)
• Genetic influences on brain structure (0)

We report the dynamic anatomical sequence of human cortical gray matter development between the age of 4–21 years using quantitative four-dimensional maps and time-lapse sequences. Thirteen healthy children for whom anatomic brain MRI scans were obtained every 2 years, for 8–10 years, were studied. By using models of the cortical surface and sulcal landmarks and a statistical model for gray matter density, human cortical development could be visualized across the age range in a spatiotemporally detailed time-lapse sequence. The resulting time-lapse ‘‘movies’’ reveal that (i) higher-order association cortices mature only after lower-order somatosensory and visual cortices, the functions of which they integrate, are developed, and (ii) phylogenetically older brain areas mature earlier than newer ones. Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism.


Human brain development is structurally and functionally a nonlinear process, and understanding normal brain maturation is essential for understanding neurodevelopmental disorders. The heteromodal nature of cognitive brain
development is evident from studies of neurocognitive performance, functional imaging (functional MRI or positronemission tomography) , and electroencephalogram coherence studies. Prior imaging studies show regional nonlinear changes in gray matter (GM) density during childhood and adolescence with prepubertal increase followed by postpubertal loss. The GM density on MRI is an indirect measure of a complex architecture of glia, vasculature, and neurons with dendritic and synaptic processes. Studies of GM maturation show a loss in corticalGMdensity over time, which temporally correlates with postmortem findings of increased synaptic pruning during adolescence and early adulthood. Here we present a study of cortical GM development in children and adolescents by using a brain-mapping technique and a prospectively studied sample of 13 healthy children (4–21 years old), who were scanned with MRI every 2 years for 8–10 years. Because the scans were obtained repeatedly on the same subjects over time, statistical extrapolation of points in between scans enabled construction of an animated time-lapse sequence (‘‘movie’’) of pediatric brain development. We hypothesized that GM development in childhood through early adulthood would be nonlinear as described before and would progress in a localized, region-specific manner coinciding with the functional maturation. We also predicted that the regions associated with more primary functions (e.g., primary motor cortex) would develop earlier compared with the regions that are involved with more complex and integrative tasks (e.g., temporal lobe).
The result is a dynamic map of GM maturation in the pre- and postpubertal period. Our results, while highlighting the remarkable heterogeneity, show that the cortical GM development appears to follow the functional maturation sequence, with the primary sensorimotor cortices along with frontal and occipital poles maturing first, and the remainder of the cortex developing in a parietal-to-frontal (back-to-front) direction. The superior temporal cortex, which contains association areas that integrate information from several sensory modalities, matured last. Furthermore, the maturation of the cortex also appeared to follow the evolutionary sequence in which these regions were created. Read the rest of this entry »

Related posts

• Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine (0)
• Genetic influences on brain structure (0)
• Negative symptoms: A review of schizophrenia, melancholic depression and Parkinson’s disease (0)
• Dynamically Spreading Frontal and Cingulate Deficits Mapped in Adolescents With Schizophrenia (0)